Timothy Bigelow

  • Associate Professor
  • Electrical and Computer Engineering (Primary Department)
  • Mechanical Engineering (Secondary Department)

Main Office

255D ASC2
Ames, IA
Phone: 515-294-4177


  • PhD, Electrical Engineering, University of Illinois at Urbana-Champaign, 2004
  • MS, Electrical Engineering, University of Illinois at Urbana-Champaign, 2001
  • BS, Electrical Engineering, Colorado State University, 1998

Interest Areas

  • Ultrasound systems to treat cancer and infections
  • Physical properties of tissue using backscattered ultrasound signals
  • Bioeffects for ultrasound safety and therapy
  • Ultrasound based quality control of additive manufacturing

Core Research Area: Bioengineering; Electromagnetics, Microwave, and Nondestructive Evaluation

Signature Research Areas: Bioengineering; Advanced Design and Manufacturing

Selected Publications

  • T.A. Bigelow, M. Oelze, and W.D. O’Brien Jr., “Estimation of total attenuation and scatterer size from backscattered ultrasound waveforms”, J. Acoust. Soc. Am., 117, 1431-1439 (2005)
  • T.A. Bigelow, R.J. Miller, J.P. Blue, and W.D. O’Brien Jr., “Hemorrhage near fetal rat bone exposed to pulsed ultrasound”, Ultrasound Med. & Biol., 33, 311-317 (2007)
  • T.A. Bigelow, B.L. McFarlin, W.D. O’Brien Jr., and M. Oelze, “In Vivo ultrasonic attenuation slope estimates for detecting cervical ripening in rats: Preliminary results”, J. Acoust. Soc. Am., 123, 1794-1800 (2008)
  • T.A. Bigelow, T. Northagen, T.M. Hill, and F.C. Sailer, “The destruction of Escherichia coli biofilms using high-intensity focused ultrasound”, Ultrasound Med. & Biol., 35, 1026-1031 (2009)
  • B.L. McFarlin, T.A. Bigelow, Y. Labyed, W.D. O’Brien Jr., M.L. Oelze, and J.S. Abramowicz, “Ultrasonic attenuation estimation of the pregnant cervix: a preliminary report”, Ultrasound in Obstetrics and Gynecology, 36, 218-225 (2010).
  • T.A. Bigelow, “Estimating the total ultrasound attenuation along the propagation path by applying multiple filters to backscattered echoes from a single spherically focused source”, IEEE Trans. Ultrason. Ferroelectr. Freq. Control., 57, 900-907 (2010)
  • Y. Labyed and T.A. Bigelow, “Estimating the total ultrasound attenuation along the propagation path by using a reference phantom”, J. Acoust. Soc. Am., 128, 3232-3238 (2010)
  • J. Xu and T.A. Bigelow, “Experimental investigation of the effect of stiffness, exposure time, and scan direction on the dimension of ultrasound histotripsy lesions”, Ultrasound Med. & Biol., 37, 1865–1873 (2011)
  • T.A. Bigelow, C.C. Church, K. Sandstrom, J.G. Abbott, M.C. Ziskin, P.D. Edmonds, B. Herman, K.E. Thomenius, and T.J. Teo, “The Thermal Index: Its strengths, weaknesses, and proposed improvements”, Journal of Ultrasound in Medicine, 30, 714-734 (2011)
  • Y. Labyed and T.A. Bigelow, “A theoretical comparison of attenuation measurement techniques from backscattered ultrasound echoes”, J. Acoust. Soc. Am., 129, 2316-2324 (2011)
  • J. Xu, T.A. Bigelow, and G.M. Riesberg, “Impact of Preconditioning Pulse on Lesion Formation During High-Intensity Focused Ultrasound Histotripsy”, Ultrasound Med. & Biol., 38, 1918-1929 (2012)
  • J. Xu, T.A. Bigelow, L.J. Halverson, J.M. Middendorf, and B. Rusk, “Minimization of treatment time for in vitro 1.1 MHz destruction of Pseudomonas aeruginosa biofilms by high-intensity focused ultrasound”, Ultrasonics, 52, 668-675 (2012)
  • Y. Labyed and T.A. Bigelow, “Optimization of the algorithms for estimating the ultrasonic attenuation along the propagation path”, Ultrasonics, 52, 720-729 (2012)
  • J. Xu, T.A. Bigelow, and E.M. Whitley, “Assessment of ultrasound histotripsy-induced damage to ex vivo porcine muscle”, Journal of Ultrasound in Medicine, 32, 69-82 (2013)
  • J. Xu, T.A. Bigelow, and R. Nagaraju, “Precision control of lesions by high-intensity focused ultrasound cavitation-based histotripsy through varying pulse duration,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control., 60, 1401-1411 (2013)
  • G. Riesberg, T.A. Bigelow, D.J. Stessman, M.H. Spalding,  L. Yao, T. Wang, and J. Xu, “Flow rate and duty cycle effects in lysis of Chlamydomonas reinhardtii using high-energy pulsed focused ultrasound,” J. Acoust. Soc. Am., 135, 3632-3638 (2014)
  • T.A. Bigelow, J. Xu, D.J. Stessman, L. Yao, M.H. Spalding, and T. Wang, “Lysis of Chlamydomonas Reinhardtii by high-intensity focused ultrasound as a function of exposure time,” Ultrasonics Sonochemistry, 21, 1258-1264 (2014)
  • V. Kumar, T.A. Bigelow, K. Mullin, D.S. Sakaguchi, “Correlation of hemorrhage near developing opossum skull to pulsed ultrasound exposure parameters”, Journal of Ultrasound in Medicine, 34, 1351-1361 (2015)
  • B.L. McFarlin , V. Kumar, T.A. Bigelow, D.G. Simpson, R.C. White-Traut, J.S. Abramowicz, and W.D. O’Brien Jr, “Beyond Cervical Length: A Pilot Study of Ultrasonic Attenuation for Early Detection of Preterm Birth Risk”, Ultrasound Med. & Biol., (2015)